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North America Real World Evidence Solutions Companies and Market Forecast

Date : 19 June 2026

Latest Updates of Companies in the North America Real World Evidence Solutions Market

North America Real World Evidence Solutions Market Companies are HealthVerity, Optum, Oracle, IQVIA, Flatiron Health

Recent Developments in the North America Real World Evidence Solutions Market

  • In January 2026, United BioSource LLC (UBC) announced it had acquired Evidinno Outcomes Research Inc. (Evidinno), a medical research access organization headquartered in Vancouver, Canada, specializing in real-world evidence (RWE), epidemiology, evidence synthesis, and advanced statistical and economic analysis.
  • In April 2025, ConcertAI announced a multi-year agreement with Bayer to leverage ConcertAI's Translational360 and AI SaaS solutions, which use artificial intelligence and machine learning (AI/ML)-driven insights to accelerate clinical development in precision cancer.

Market Ecosystem Analysis

Ecosystem Category Key Participants Role in Market
Technology Providers IQVIA, Oracle, Merative, SAS Institute Provide data integration, analytics, AI, cloud infrastructure, and evidence-generation platforms
Product Manufacturers Flatiron Health, Aetion, TriNetX Develop RWE software, disease-specific datasets, and analytics products
Service Providers Syneos Health, Parexel, ICON plc Deliver RWE study design, execution, regulatory support, and consulting
Platform Providers IQVIA, Optum, Oracle, Merative, Flatiron Health Operate large-scale RWD platforms and evidence-generation environments
CROs/CDMOs ICON plc, Parexel, Syneos Health, Medpace, Thermo Fisher Scientific (PPD) Conduct RWE studies and integrate evidence into development programs
Software Vendors SAS Institute, Oracle, Cognizant, NTT DATA Provide analytics, AI, interoperability, and healthcare data management software
Research Institutions FDA Sentinel collaborators, Harvard Medical School, Mayo Clinic, Johns Hopkins University, Duke Clinical Research Institute Advance RWE methodologies and validation frameworks
End-User Industries Pharma, Biotechnology, Medical Devices, Diagnostics, Payers, Providers Utilize RWE for development, reimbursement, safety, and commercialization decisions

Supply Chain Analysis

R&D:

  • Research and development (R&D) in North America real-world evidence solutions involves data sourcing, data curation and standardization, study design and protocol development, advanced analytics and modelling, and evidence generation and translation.
  • Key Players:Flatiron Health and Aetion

Manufacturing Processes:

  • Major manufacturing processes involve data ingestion, data normalization, advanced analytics, and regulatory validation.
  • Key Players: HealthVerity and IQVIA

Patient Services:

  • Significant patient services are patient support programs, patient-reported outcomes, consent management, and privacy operations.
  • Key Players: Optum and Oracle
Tier 1
Company Name Headquarters Country Why Relevant to This Market Key Products/Services Related to Keyword
IQVIA Durham, North Carolina USA Widest healthcare data assets and largest dedicated RWE organization globally IQVIA RWE Solutions, E360 Platform, HEOR, regulatory evidence generation
Optum Eden Prairie, Minnesota USA One of the largest claims and payer data owners in North America Optum Life Sciences, claims analytics, outcomes research
Oracle Austin, Texas USA Major healthcare data and analytics infrastructure provider Oracle Health, healthcare data platforms, evidence analytics
Merative Ann Arbor, Michigan USA Strong RWD analytics and healthcare intelligence capabilities MarketScan, Micromedex, evidence analytics
Flatiron Health New York, New York USA Dominant oncology-focused RWE provider with deep EHR-derived datasets Flatiron Real-World Data, oncology evidence platforms
Tier 2
Company Name Headquarters Country Why Relevant to This Market Key Products/Services Related to Keyword
ICON plc Dublin Ireland Leading CRO with significant RWE and HEOR operations in North America RWE studies, HEOR, regulatory evidence services
Parexel Durham, North Carolina USA Major evidence-generation and market access provider Real-world studies, observational research
Syneos Health Morrisville, North Carolina USA Strong integrated clinical and commercial evidence capabilities RWE consulting, post-market evidence, HEOR
Thermo Fisher Scientific (PPD) Waltham, Massachusetts USA Extensive RWE services integrated with clinical development PPD RWE, epidemiology, outcomes research
Medpace Cincinnati, Ohio USA Growing CRO with dedicated observational and RWE programs Non-interventional studies, registry studies
Tier 3
Company Name Headquarters Country Why Relevant to This Market Key Products/Services Related to Keyword
Aetion New York, New York USA Industry-leading causal inference and regulatory-grade RWE platform Aetion Evidence Platform
TriNetX Cambridge, Massachusetts USA Large federated clinical research network Clinical data network, feasibility and RWE analytics
HealthVerity Philadelphia, Pennsylvania USA Specialized patient identity resolution and linked RWD assets Data linkage and evidence-generation solutions
OM1 Boston, Massachusetts USA AI-driven real-world outcomes and disease intelligence platform OM1 Real-World Data Cloud
ConcertAI Cambridge, Massachusetts USA Rapidly growing oncology and precision medicine RWE provider CancerLinQ-linked datasets, AI-enabled evidence generation

Market Growth

The North America real world evidence solutions market size stood at US$ 1.98 billion in 2025, grew to US$ 2.25 billion in 2026, and is forecast to reach US$ 7.21 billion by 2035, expanding at a CAGR of 13.8% from 2026 to 2035.

North America Real World Evidence Solutions Market Size is USD 2.25 Billion in 2026.

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